Custom Peptides
Cayman Chemical 10-Gngerol 10mg
A phenol with diverse biological activities; scavenges DPPH, superoxide, and hydroxyl radicals in cell-free assays (IC50s = 10.47, 1.68, and 1.35 µM, respectively); inhibits fMLP-induced oxidative burst in isolated human PMN neutrophils at 6 µM; inhibits NETosis and the production of ROS induced by LPS or lupus-relevant stimuli in isolated human neutrophils; active against M. avium and M. tuberculosis (MICs = 25 and 50 UG/ml, respectively); cytotoxic to human MDA-MB-231 and MDA-MB-468 and murine 4T1 and EO771 mammary carcinoma cells at 200 µM
Cayman Chemical Decnoyl-L-carnItInchlorId 10mg
A derivative of L-carnitine; increases the formation of C24 fatty acid intermediates, as well as docosapentaenoic and docosahexaenoic acid in rat hepatocytes
Cayman Chemical Juglns regIa L. JuglaIn 10mg
A flavonol with diverse biological activities; reduces OSS-induced increases in ROS in HAECs at 2.5 and 5 µM; inhibits the proliferation of, as well as induces JNK activation, autophagosome formation, apoptosis, and cell cycle arrest at the G2/M phase in, MCF-7 human breast cancer cells at 2.5, 5, and 10 µM; reduces tumor growth in an MCF-7 mouse xenograft model at 10 and 20 mg/kg; reduces body weight, renal fibrosis, and blood glucose levels, as well as serum and renal levels of Tnf-α, Il-1β, Il-6, and Ccl2, and improves glucose tolerance in a mouse model of high-fat diet- and obesity-induced kidney disease at 15 and 30 mg/kg
Cayman Chemical DIbutyl3Hydroybutyl phsph 10mg
A compound produced from the metabolism of the organophosphorus solvent, TBP
Cayman Chemical TetrabenazIn-d6 10mg
An internal standard for the quantification of tetrabenazine by GC- or LC-MS
Cayman Chemical 1PalmItoyl2Stearoyl3Oleo 10mg
A triacylglycerol; has been detected in RAW 264.7 cells by neutral loss MS; increased serum levels are a potential biomarker for NAFLD
Cayman Chemical 4methoxy5HydroxycnthIn6 10mg
An alkaloid with anti-inflammatory activity; reduces LPS-induced TNF-α release from, and NO production in, RAW 264.7 macrophages at 10, 30, and 100 µM; reduces paw swelling in a rat model of CFA-induced arthritis at 9 and 27 mg/kg; reduces colonic inflammatory cytokine levels and maintains mucosal barrier function in a mouse model of DSS-induced colitis from 25-100 mg/kg
Cayman Chemical ndocromIlsodIum salt 10mg
A mast cell stabilizer; inhibits IgE-induced histamine release from MC/3T3 cells preincubated with IL-2 at 10 µM; prevents EArly- and late-phase bronchoconstriction in a guinea pig model of asthma induced by ovalbumin; prevents conjunctival edema and erythema and reduces mast cell degranulation in a rat model of conjunctivitis at 2 mg/kg
Cayman Chemical PPACKhydrochlorIde 10mg
A synthetic peptide derivative that irreversibly and specifically inhibits thrombin-mediated platelet activation by binding with high affinity to the active site of thrombin (Ki = 0.24 nM); used as an anticoagulant (100 μM)
Cayman Chemical PhosphatIdylethnolamInsoy 10mg
A mixture of phosphatidylethanolamines isolated from soy; comprises approximately 25% of total mammalian phospholipids and almost 50% of brain phospholipids; found mainly in the cell membrane; synthesized mainly in the ER and mitochondrial membranes; acts as a chaperone in E. coli for lactose permease assembly; cofactor for prion propagation that can convert recombinant mammalian proteins into infectious molecules
Cayman Chemical SwertIamarIn 10mg
A secoiridoid glycoside with diverse biological activities; scavenges ABTS radicals and hydrogen peroxide (IC50s = 2.83 and 5.7 μM, respectively); inhibits NO production in IL-1β-stimulated FLSs isolated from rat hindpaw at 50 μg/ml; inhibits oleate-induced lipid droplet and triglyceride accumulation in HepG2 cells at 25 μg/ml; decreases liver lipid accumulation, ballooning degeneration, and TNF-α and IL-6 levels in a mouse model of fructose-induced NAFLD at 50 mg/kg per day; decreases fasting blood glucose and serum cholesterol levels in rat model of STZ-induced diabetes at 50 mg/kg per day
Cayman Chemical C17 CeramIded18 117 0 10mg
A synthetic ceramide; contains a non-natural C17:0 fatty acid acylated to sphingosine; has been used as a marker of arylsulfatase A and sphingolipid activator B activity
Cayman Chemical CeralIfImod 10mg
An agonist of S1P1 and S1P5 receptors (Kis = 0.626 and 0.574 nM, respectively); selective for S1P1 and S1P5 over S1P2-4 (Kis = >5,450, >5,630, and 28.8 nM, respectively); induces calcium influx in CHO-K1 cells overexpressing S1P1 (EC50 = 1 nM) and cAMP accumulation in CHO-K1 cells overexpressing S1P1 or S1P5 (EC50s = 0.027 and 0.33 nM, respectively); reduces paw edema in a rat model of CIA at 0.03 and 0.1 mg/kg; delays disease onset and inhibits lymphocyte infiltration of the spinal cord in a rat model of EAE; prevents disease relapse in a non-obese diabetic mouse model of relapsing-remitting EAE
Cayman Chemical MagnoflorIn 10mg
An alkaloid with diverse biological activities; reduces LPC-induced hemolysis in a rat erythrocyte suspension from 0.01-10 μM; induces intracellular chloride influx in neuroblastoma cells at 10 μM; reduces TNF-α-induced NF-κB expression as well as production of IL-6 and IL-8 in BEAS-2B cells; improves short- and long-term memory acquisition in a passive avoidance test in a mouse model of scopolamine-induced memory impairment at 20 mg/kg
Cayman Chemical NDT 9513727 10mg
A competitive antagonist of C5aR (IC50 = 11.6 nM for the human recombinant receptor); has inverse agonist activity; selective for human recombinant over rat and mouse recombinant C5aRs (IC50 = >10 µM for both) but does have activity at macaque and gerbil receptors (IC50s = 7.3 and 6.4 nM, respectively); inhibits degranulation in C5a-stimulated U937 cells (IC50 = 7.1 nM); prevents C5a-induced neutropenia in gerbils (ED50 = 2.2 mg/kg) and in cynomolgus macaques at 5 and 25 mg/kg